DHANANSAYAN SHANMUGANAYAGAM, PHD

Assistant Professor in Animal Science
dshanmug@wisc.edu

608.890.1396

Department of Animal Science;
1675 Observatory Drive

Research Interests:Genetic swine models of human diseases.

Research

Focus on the development and utilization of novel swine models of human disease for elucidating mechanisms and discovering targets for development of diagnostic and therapeutic technologies. The genetic proximity of swine to humans and the overwhelming similarities in anatomy, physiology, and nutrition make swine the ideal model for preclinical studies of the interaction between genetics and nutrition as it relates to diseases. I believe that the use of such highly translational models accelerate the rate at which discoveries can be developed into applications and technologies that benefit human and animal health.

Patents & Applications 

Tannin-containing gastrointestinal formulations and methods of use Publication date: 2014-07-14 Publication number: US20140200266A1

Publications
  • Feliciano RP, Meudt JJ, Shanmuganayagam D, Metzger BT, Krueger CG, Reed JD.Supercritical fluid extraction (SFE) of cranberries does not extract oligomeric proanthocyanidins (PAC) but does alter the chromatography and bioactivity of PAC fractions extracted from SFE residues. J Agric Food Chem. 2014 Jul 14.
  • Johnson LL, Tekabe Y, Kollaros M, Eng G, Bhatia K, Li C, Krueger CG, Shanmuganayagam D, Schmidt AM. Imaging RAGE expression in atherosclerotic plaques in hyperlipidemic pigs. EJNMMI Res. 2014 Jun 11;4:26.
  • Wentland, A.L., O. Wieben, D. Shanmuganayagam, C.G. Krueger, J. J. Meudt, D. Consigny, L. Rivera, P.E. McBride, J.D. Reed, T.M Grist. Measurements of wall shear stress and aortic pulse wave velocity in swine with familial hypercholesterolemia. J Magn Reson Imaging. 2014.
  • Pierre, J.F, A.F. Heneghan, R.P. Feliciano, D. Shanmuganayagam, C.G. Krueger,  J.D. Reed, K.A. Kudsk. Cranberry proanthocyanidins improve intestinal sIgA during elemental enteral nutrition. J Parenter Enter Nutr.. 2014; 38:107-114.
  • Feliciano, R.P., J.J. Meudt, D. Shanmuganayagam, C.G. Krueger and J.D. Reed. Ratio of “A-type” to “B-type” proanthocyanidin interflavan bonds affects extraintestinal Pathogenic Escherichia coli invasion of gut epithelial cells. J Agric Food Chem. 2013;
  • Heneghan AF, Pierre JF, Tandee K, Shanmuganayagam D, Wang X, Reed JD, Steele JL, Kudsk KA. Parenteral nutrition decreases paneth cell function and intestinal bactericidal activity while increasing susceptibility to bacterial enteroinvasion. J Parenter Enteral Nutr. 2013 Jul 26.
  • Pierre, J.F, A.F. Heneghan, J.M. Meudt, M.P. Shea, C.G. Krueger, J.D. Reed, K.A.  Kudsk, D. Shanmuganayagam. Parenteral nutrition increases susceptibility of ileum invasion by E. coli. J Surg Res. 2013; 183: 583-591.
  • Pierre, J.F, A.F. Heneghan, R.P. Feliciano, D. Shanmuganayagam, D.A.  Roenneburg, C.G. Krueger, J.D. Reed, K.A. Kudsk. Cranberry proanthocyanidins improve the gut mucous layer morphology and function in mice receiving elemental enteral nutrition. J Parenter Enter Nutr. 2013; 37: 401-409.
Mentor to METC Graduate Students:
  • Folagbayi Arowolo (Current)