DUDLEY LAMMING, PHD

The Lamming laboratory’s goal is to understand how nutrient-responsive signaling pathways can be harnessed to promote health and longevity. We are primarily focused on the physiological role played by the mechanistic target of rapamycin (mTOR), a protein kinase that through a diverse set of substrates regulates complex cellular processes, including growth, metabolism, and aging. Recent work has shown that rapamycin, an inhibitor of mTOR signaling, can improve both health and longevity in model organisms including mammals. Understanding and manipulating the mTOR signaling pathway through dietary, pharmaceutical or genetic interventions in mouse models may provide insight into the treatment of age-related diseases, including diabetes, Alzheimer’s disease, cancer, and Hutchinson-Gilford Progeria Syndrome.

Publications

• Fontana L, Cummings NE, Arriola Apelo SI, Neuman JC, Kasza I, Schmidt BA, Cava E, Spelta F, Tosti V, Syed FA, Baar EL, Veronese N, Cottrell SE, Fenske RJ, Bertozzi B, Brar HK, Pietka T, Bullock AD, Figenshau RS, Andriole GL, Merrins MJ, Alexander CM, Kimple ME, Lamming DW#. Decreased consumption of branched chain amino acids improves glycemic control. Cell Reports, 2016, June 23
• Strong R, Miller RA, Antebi A, Astle CM, Bogue M, Denzel MS, Fernandez E, Flurkey K, Hamilton KL, Lamming DW, Javors MA, de Magalhães JP, Martinez PA, McCord JM, Miller BF, Müller M, Nelson JF, Ndukum J, Rainger GE, Richardson A, Sabatini DM, Salmon AB, Simpkins JW, Steegenga WT, Nadon NL, Harrison DE. Longer lifespan in male mice treated with a weakly estrogenic agonist, an antioxidant, an α-glucosidase inhibitor or a Nrf2-inducer. Aging Cell. 2016 Jun 16. doi: 10.1111/acel.12496.
• Kennedy BK, Lamming DW. The mechanistic Target of Rapamycin: The grand conducTOR of metabolism and aging. Cell Metabolism, 2016; 23(6):990-1003. doi: 10.1016/j.cmet.2016.05.009. Pubmed PMID: 27304501 PubMed Central PMCID: PMC4910876.
• Gregg T, Poudel C, Schmidt BA, Dhillon RS, Sdao SM, Truchan NA, Baar EL, Fernandez LA, Denu JM, Eliceiri KW, Rogers JD, Kimple ME, Lamming DW, Merrins MJ. Pancreatic β cells from Mice Offset Age-Associated Mitochondrial Deficiency with Reduced KATP Channel Activity. Diabetes. 2016 Jun 9. pii: db160432.
• Arriola Apelo SI, Lamming DW. Rapamycin: An InhibiTOR of Aging Emerges From the Soil of Easter Island. J Gerontol A Biol Sci Med Sci. 2016 Jul;71(7):841-9. doi: 10.1093/gerona/glw090.
• Gregg T, Poudel C, Schmidt BA, Dhillon RS, Sdao SM, Truchan NA, Baar EL, Fernandez LA, Denu JM, Eliceiri KW, Rogers JD, Kimple ME, Lamming DW#, Merrins MJ#. Pancreatic β cells from Mice Offset Age-Associated Mitochondrial Deficiency with Reduced KATP Channel Activity. Diabetes, 2016 Jun 9. pii: db160432. [Epub ahead of print] Pubmed PMID: 27284112 PubMed Central PMCID: In progress
• Arriola Apelo SI, Pumper CP, Baar EL, Cummings NE, Lamming DW. Intermittent administration of rapamycin extends the lifespan of female C57BL/6J mice. J Geron Biol Sci, 2016, Apr 18. pii: glw064. [Epub ahead of print]. PMID: 27091134 PMCID: PMC4906329.
• Arriola Apelo SI, Lamming DW. Rapamycin: An InhibiTOR of Aging Emerges From The Soil of Easter Island. J Geron Biol Sci, 2016, May 21. pii: glw090. [Epub ahead of print]. Pubmed PMID: 27208895; PubMed Central PMCID: PMC4906330.
• Beyaz S, Mana MD, Roper J, Kedrin D, Saadatpour A, Hong SJ, Bauer-Rowe KE, Xifaras ME, Akkad A, Arias E, Pinello L, Katz Y, Shinagare S, Abu-Remaileh M, Mihaylova MM, Lamming DW, Dogum R, Guo G, Bell GW, Selig M, Nielsen GP, Gupta N, Ferrone CR, Deshpande V, Yuan GC, Orkin SH, Sabatini DM, Yilmaz ÖH. High-fat diet enhances stemness and tumorigenicity of intestinal progenitors. Nature. 2016 Mar 3;531(7592):53-8. doi: 10.1038/nature17173.
• Covarrubias AJ, Aksoylar HI, Yu J, Snyder NW, Worth AJ, Iyer SS, Wang J, Ben-Sahra I, Byles V, Polynne-Stapornkul T, Espinosa EC, Lamming D, Manning BD, Zhang Y, Blair IA, Horng T. Akt-mTORC1 signaling regulates Acly to integrate metabolic input to control of macrophage activation. Elife. 2016 Feb 19;5. pii: e11612. doi: 10.7554/eLife.11612.
• Tran CM, Mukherjee S, Ye L, Frederick DW, Kissig M, Davis JG, Lamming DW, Seale P, Baur JA. Rapamycin Blocks Induction of the Thermogenic Program in White Adipose Tissue.
  Diabetes. 2016 Apr;65(4):927-41. doi: 10.2337/db15-0502. Epub 2016 Feb 8.
• Baar EL, Carbajal KA, Ong IM, Lamming DW. Sex- and tissue-specific changes in mTOR signaling with age in C57BL/6J mice. Aging Cell. 2016 Feb;15(1):155-66. doi: 10.1111/acel.12425. Epub 2015 Nov 24.
• Arriola Apelo SI, Neuman JC, Baar EL, Syed FA, Cummings NE, Brar HK, Pumper CP, Kimple ME, Lamming DW. Alternative rapamycin treatment regimens mitigate the impact of rapamycin on glucose homeostasis and the immune system. Aging Cell. 2016 Feb;15(1):28-38. doi: 10.1111/acel.12405. Epub 2015 Oct 13.
• Lamming DW, Cummings NE, Rastelli AL, Gao F, Cava E, Bertozzi B, Spelta F, Pili R, Fontana L. Restriction of dietary protein decreases mTORC1 in tumors and somatic tissues of a tumor-bearing mouse xenograft model. Oncotarget. 2015 Oct 13;6(31):31233-40. doi: 10.18632/oncotarget.5180.
• Lamming DW. Diminished mTOR signaling: a common mode of action for endocrine longevity factors. Springerplus. 2014 Dec 15;3:735. doi: 10.1186/2193-1801-3-735. eCollection 2014. Review.
• Lamming DW. Hot topics at the intersection of aging and energetics: Diabetes/insulin resistance, Sirtuins, and the Microbiome. F1000Res. 2014 Oct 28;3:257. doi: 10.12688/f1000research.5625.1. eCollection 2014.
• Liu Y, Diaz V, Fernandez E, Strong R, Ye L, Baur JA, Lamming DW, Richardson A, Salmon AB. Rapamycin-induced metabolic defects are reversible in both lean and obese mice. Aging (Albany NY). 2014 Sep;6(9):742-54.
• Lamming DW. mTORC2 takes the longevity stAGE. Oncotarget. 2014 Sep 15;5(17):7214-5. No abstract available.
• Lamming DW, Mihaylova MM, Katajisto P, Baar EL, Yilmaz OH, Hutchins A, Gultekin Y, Gaither R, Sabatini DM. Depletion of Rictor, an essential protein component of mTORC2, decreases male lifespan. Aging Cell. 2014 Oct;13(5):911-7. doi: 10.1111/acel.12256. Epub 2014 Jul 25.
• Efeyan A, Schweitzer LD, Bilate AM, Chang S, Kirak O, Lamming DW, Sabatini DM. RagA, but not RagB, is essential for embryonic development and adult mice. Dev Cell. 2014 May 12;29(3):321-9. doi: 10.1016/j.devcel.2014.03.017. Epub 2014 Apr 24.
• Soliman MA, Abdel Rahman AM, Lamming DW, Birsoy K, Pawling J, Frigolet ME, Lu H, Fantus IG, Pasculescu A, Zheng Y, Sabatini DM, Dennis JW, Pawson T. The adaptor protein p66Shc inhibits mTOR-dependent anabolic metabolism. Sci Signal. 2014 Feb 18;7(313):ra17. doi: 10.1126/scisignal.2004785. Erratum in: Sci Signal. 2014 Mar 4;7(315):er2. Lamming, Dudley A [corrected to Lamming, Dudley W].

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Mentor to METC Graduate Students: 

• Deyang Yu (2019)