Professor in Medical Sciences
ltrepanier@svm.vetmed.wisc.edu
608/265-9022
4254 Veterinary Medicine Building
Research Interests:Drug hypersensitivity. Drug and carcinogen detoxification. Pharmacogenetics.
Research
Dr. Trepanier’s research is on genetically determined differences in drug biotransformation and their effects on the individual risk of drug toxicity or cancer outcomes. The major focus of her laboratory is on the mechanisms of risk for sulfonamide drug hypersensitivity reactions in immunocompetent and HIV-infected patients.
Publications
- Funk-Keenan J, Sacco J, Wong YY, Rasmussen S, Motsinger-Reif A, Trepanier LA. Evaluation of polymorphisms in the sulfonamide detoxification genes CYB5A and CYB5R3 in dogs with sulfonamide hypersensitivity. J Vet Intern Med. 6:1126-33, 2012.
- Abouraya M, Sacco JS, Hayes K, Thomas S, Kitchens C, Trepanier LA. Dapsone-associated methemogobinemia in a patient with slow NAT2*5B haplotype and impaired cytochrome b5 reductase activity. J Clin Pharmacol 52:272-278, 2012. PMC3153586.
- Sacco J, Abouraya M, Motsinger-Reif A, Yale S, McCarty C, Trepanier LA. Evaluation of polymorphisms in the sulfonamide detoxification genes NAT2, CYB5A, and CYB5R3 in patients with sulfonamide hypersensitivity. Pharmacogenet Genom. 22:733-40, 2012. PMC3619396..
- Ginn J, Sacco J, Wong YY, Motsinger-Reif A, Chun R, and Trepanier LA. Positive association between a glutathione-S-transferase (GSTT1) polymorphism and lymphoma in dogs. Vet Comp Oncol 12:227-236, 2014.
- Blanke K, Sacco J, Millikan R, Olshan AF, Luo J, Trepanier LA. Polymorphisms in the carcinogen detoxification genes CYB5A and CYB5R3 and breast cancer risk in African American women. Cancer Causes and Control. 25:1513-21, 2014.
Mentor to METC Graduate Students:
- Hannah Peterson (Current)
- Kristina Blanke (2014)
- Keelia Rhodes (2010)
- Joe Kurian (2006)