Professor in Admin/Basic Research
3750 Medical Sciences Center
Research Interests:Signal Transduction Mechanisms that control cellular functions and disease.
Our major research focus has the objective of understanding phosphoinositide (PI) and inositol phosphate signal transduction pathways that impact cellular regulatory events. All eukaryotic cells are regulated by phosphoinositide signals. In phosphoinositide signaling, PI, a phospholipid, is sequentially phosphorylated on the inositol ring to form essential signaling molecules such phosphatidylinositol-4,5-bisphosphate (PI4,5P2). PI4,5P2 is directly synthesized by phosphatidylinositol-phosphate kinases (PIPKs), and PI4,5P2 occupies an essential position in PI signaling by directly regulating cellular functions that include cell proliferation, secretion, cytoskeletal assembly and cell motility. In addition, PI4,5P2 is a key transducer of cellular signals as a precursor for many second messengers. The PIPKs define an enzyme superfamily responsible for the generation of all PI derived second messengers, demonstrating that these kinases have roles in many cellular functions. The different PIPK family members are targeted to subcellular compartments by specific protein-protein interactions. The interactions between the PIPKs and targeting proteins results in spatial and temporal generation of PI4,5P2 that regulates specific cellular functions. Lab
- Tan, X., Thapa, N., Sun, Y. & Anderson, R.A. (2015) A kinase-independent role for EGF receptor in autophagy initiation. Cell 160, 145-160. PMID: 25594178, PMCID: PMC4297316. News release UW, Emphasized in Science Comments, Oncology-central, Science Daily, Cancer Discovery – News in Brief, “Study Illuminates How Cancers Evade EGFR Inhibitors”
- Tan X, Sun Y, Thapa N, Liao Y, Hedman AC, Anderson RA. (2015) LAPTM4B is a PtdIns(4,5)P2 effector that regulates EGFR signaling, lysosomal sorting, and degradation. The EMBO journal. PMID: 25588945, “PMCID: PMC Journal — In Process”
- Choi, S., Thapa, N., Tan, X., Hedman, A.C., Anderson, R.A. (2014) PIP kinases define PI4,5P2 signaling specificity by association with effectors. BBA – Molecular and Cell Biology of Lipids, In press.
- Li*, W., Laishram*, R.S., Ji*, Z., Hoque, M., Tian, B., and Anderson, R.A. (2015) Genome-wide Alternative Polyadenylation is Specifically Regulated by the Different Nuclear Poly(A) Polymerases. *Co-first authors. In revision, Nature.Communications.
- Thapa, N., Choi, S., Tan, X., and Anderson, R. A. (2015) Phosphatidylinositol Phosphate 5-Kinase Igamma and PI3K/Akt Signaling Couple to Promote Oncogenic Growth. In revision, J. Biol. Chem.
- Hedman, A.C., Sun, Y., Tan, X., and Anderson, R. A. (2015) Phosphoinositide Regulation of SNX5 and SNX6 Is Required for EGFR Lysosomal Degradation. In revision, J. Biol. Chem.
- Hedman, A.C., Sun, Y., Tan, X., and Anderson, R. A. (2015) Endosomal Phosphatidylinositol 4,5 Bisphosphate Controls EGFR Signaling and Degradation. In submission.
- Laishram, R.S., Ji, Z., Tian, B., and Anderson. R.A. (2015) Star-PAP Phosphorylation at the Zinc-Finger Regulates PIPKIα Interaction and Specificity of Target mRNA Expression. In submission.
- Laishram, R.S., Ji, Z., Tian, B., and Anderson. R.A. (2015) Star-PAP Controls Expression of NQO1 by Regulation of Alternative Polyadenylation by Distinct Pathways and Mechanisms. In preparation.
- Li, W., Laishram, R.S., Ji, Z., Tian, B., and Anderson. R.A. (2015) Star-PAP Regulates p53 by Controlling PTEN, AKT, and MDM2 Expression by Alternative Polyadenylation. In preparation.
- Sun, Y., Tan, X. and Anderson, R.A. (2015) Endosomal Type Ig PIP 5-Kinase Controls Degradation of MIG-6 an Endogenous EGF Receptor Inhibitor and Tumor Suppressor. In preparation.
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