VINCENT CRYNS, MD

Research

Lab focus is on understanding how cells die. Especially interested in elucidating how abnormalities in cell death contribute to the pathogenesis of cancer and obesity and in translating these insights into improved therapies. The Cryns lab studies the molecular origins of cancer and obesity and the links between these diseases. We use a multidisciplinary approach that incorporates molecular profiling and nanotechnology to translate these insights into improved therapies.

Publications

• Malin D, Strekalova E, Petrovic V, Deal AM, Al Ahmad A, Adamo B, Miller CR, Ugolkov A, Livasy C, Fritchie K, Hamilton E, Blackwell K, Geradts J, Ewend M, Carey L, Shusta EV, Anders CK, Cryns VL. alphaB-crystallin: a novel regulator of breast cancer metastasis to the brain. Clin Cancer Res 2014 20:56-67.
• Moyer TJ, Finbloom J, Chen F, Toft DJ, Cryns VL, Stupp SI. pH and amphiphilic structure direct supramolecular behavior in biofunctional assemblies. J Am Chem Soc 2014 136:14746-52.
• Halo TL, McMahon KM, Angeloni NL, Xu Y, Wang W, Chinen AB, Malin D, Strekalova E, Cryns VL, Cheng C, Mirkin CA, Thaxton CS. NanoFlares for the detection, isolation, and culture of live tumor cells from human blood. Proc Natl Acad Sci USA 2014 111:17104-9.
• Malin D, Strekalova E, Petrovic V, Rajanala H, Sharma B, Ugolkov A, Gradishar WJ, Cryns VL. ERK-regulated alphaB-crystallin induction by matrix detachment inhibits anoikis and promotes lung metastasis in vivo. Oncogene 2015 In Press.
• Strekalova E, Malin D, Good DM, Cryns VL. Methionine deprivation induces a targetable vulnerability in triple-negative breast cancer cells by enhancing TRAIL receptor-2 expression. Clin Cancer Res 2015 In Press.